I-High Purity Metformin CAS 657-24-9 Metformin Manufacturer
Ingcaciso yeMveliso
I-Metformin: Ichiza elinamandla lokunyanga isifo seswekile
1.Yintoni i-metformin?
IBiguanides ifumaneka kwingca yebhokhwe (Galega Officinalis), isityalo ebesisetyenziswa kumayeza esintu amakhulu eminyaka. Isenzo se-pharmacological yesityalo ngokwaso sixhomekeke kwibhokhwe (Isoamylene guanidine). I-Phenformin, i-Buformin, kunye ne-metformin zonke zenziwe ngamachiza kwaye zineemolekyuli ezimbini ze-guanidine. I-Metformin lichiza lomlomo elisetyenziswa ngokubanzi ukunyanga uhlobo lwe-2 yeswekile. Iphuma kudidi lwamachiza abizwa ngokuba yi-biguanides kwaye ithathwa njengonyango lodidi lokuqala lwesifo seswekile.
2.Isebenza njani i-metformin?
Owona msebenzi weMetformin kukunciphisa umthamo weswekile oveliswa sisibindi kwaye wenze iiseli zomzimba zibe novelwano ngakumbi kwi-insulin. Yehlisa ngokufanelekileyo amanqanaba eswekile yegazi kwaye inceda ukulawula impendulo yomzimba kwi-insulin.
I-Metformin ilawula iswekile yegazi ikakhulu ngokuthintela ukuphuma kweswekile yesibindi. I-Metformin ixhomekeke kakhulu kwi-organic cationic transporter 1 (OCT 1) yokungena kwi-hepatocytes, kwaye emva koko inqanda ngokuyinxenye i-mitochondrial ye-respiration chain complex 1, okubangelwa ukunciphisa i-ATP ye-intracellular kunye nokunyuka kwamanqanaba e-AMP. Sonke siyazi ukuba ukuhla kwe-ATP kunye nokunyuka kwe-AMP kwiseli kuya kuthintela ngokuthe ngqo i-gluconeogenesis kunye nokunciphisa ukuguqulwa kwe-glycerol kwi-glucose.
Ukunyuka kwe-AMP / ATP ratio ebangelwa yi-metformin iphinda isebenze indlela yokubonisa i-AMPK, evimbela ukuhlanganiswa kwamafutha kunye nokwandisa uvakalelo lomzimba kwi-insulin.
3.Ziziphi iingenelo ze-metformin?
I-Metformin ibonelela ngeenzuzo ezininzi kubantu abanesifo seswekile:
I-1) Ukulawulwa kweswekile yegazi: Ngokunciphisa imveliso yeswekile kwisibindi kunye nokuphucula ukuvakalelwa kwe-insulin, i-metformin inceda ukulawula amanqanaba eshukela egazi kwaye ibakhusele ukuba bahambe kakhulu okanye baphantsi kakhulu.
2) Ukulawulwa kobunzima: I-Metformin idla ngokubangela ukulahleka kwesisindo esilinganiselweyo kubantu abanesifo sikashukela. Ikwenza oku ngokunciphisa umdla wokutya, ukwandisa iimvakalelo zokuzala, kunye nokunceda ukungena kwi-glucose kunye neevenkile zamafutha zamandla.
I-3) Ukukhuselwa kwe-Cardiovascular: Uphononongo lubonisa ukuba i-metformin inokunciphisa umngcipheko wesifo senhliziyo, njengesifo senhliziyo kunye nesifo, kubantu abanesifo sikashukela.
I-4) I-Polycystic ovary syndrome (PCOS): Ngaphandle kokunyanga isifo sikashukela, i-metformin isetyenziselwa ukuphatha i-PCOS, i-hormone disorder disorder echaphazela abafazi. Inceda ukulawula umjikelo wokuya exesheni, inciphisa ukuxhathisa kwe-insulin, kwaye inceda ekuchumeni.
4.Inokusetyenziswa phi i-metformin?
I-Metformin isetyenziselwa ikakhulu ukunyanga isifo seswekile se-2. Ingasetyenziswa yodwa okanye idityaniswe namanye amayeza omlomo we-antidiabetic okanye idityaniswe nonyango lwe-insulin, kuxhomekeke kwiimfuno zomntu ngamnye. I-Metformin iboniswa ukuba isetyenziswe kubantu abasandul 'ukuxilongwa kunye nakubantu abanolawulo olude lwesifo seswekile. Isishwankathelo, i-metformin lichiza elinamandla elisetyenziswa ngokubanzi ukunyanga uhlobo lwe-2 yeswekile kunye ne-PCOS. Ineenzuzo ezinjengokulawula iswekile yegazi, ulawulo lobunzima, ukukhuselwa kwentliziyo, kunye nokukhululeka kweempawu ze-PCOS. Ngenxa yokusebenza kwayo kunye nokusetyenziswa ngokubanzi, i-metformin iye yaba sisixhobo esibalulekileyo ekuncedeni abantu baphile ubomi obunempilo ngelixa belawula ngokufanelekileyo imeko yabo.
Ukutya
Ukwenza mhlophe
Iipilisi
Ukwakhiwa Kwezihlunu
Izongezo zokutya
Iprofayile yekhampani
I-Newgreen lishishini elikhokelayo kwicandelo lezongezo zokutya, elasekwa ngo-1996, lineminyaka engama-23 yamava okuthumela ngaphandle. Ngeteknoloji yokuvelisa iklasi yokuqala kunye neworkshop yemveliso ezimeleyo, inkampani iye yanceda uphuhliso loqoqosho lwamazwe amaninzi. Namhlanje, iNewgreen inebhongo ngokubonisa into entsha-uluhlu olutsha lwezongezo zokutya ezisebenzisa itekhnoloji ephezulu ukuphucula umgangatho wokutya.
ENewgreen, ukusungula izinto ezintsha yeyona nto iqhubayo emva kwayo yonke into esiyenzayo. Iqela lethu leengcali lihlala lisebenza ekuphuhliseni iimveliso ezintsha kunye neziphuculweyo ukuphucula umgangatho wokutya ngelixa kugcinwa ukhuseleko kunye nempilo. Sikholelwa ukuba ukusungula izinto ezintsha kunokusinceda soyise imiceli mngeni yehlabathi lanamhlanje elikhawulezayo kwaye siphucule umgangatho wobomi babantu kwihlabathi liphela. Uluhlu olutsha lwezongezo luqinisekisiwe ukuhlangabezana nemigangatho ephezulu yamazwe ngamazwe, ukunika abathengi uxolo lwengqondo.Sizama ukwakha ishishini elizinzileyo kunye nenzuzo elingazisi nje impumelelo kubasebenzi bethu kunye nabanini-zabelo, kodwa linegalelo kwihlabathi elingcono kubo bonke.
I-Newgreen inebhongo ngokubonisa ubuchwepheshe bayo obuphezulu-umgca omtsha wezongezo zokutya eziza kuphucula umgangatho wokutya kwihlabathi jikelele. Inkampani kudala izibophelele ekuveliseni izinto ezintsha, ingqibelelo, iphumelele, nasekukhonzeni impilo yabantu, kwaye iliqabane elithembekileyo kwishishini lokutya. Ukujonga kwikamva, sonwabile ngamathuba akhoyo kwitekhnoloji kwaye sikholelwa ukuba iqela lethu elizinikeleyo leengcali liya kuqhubeka nokubonelela abathengi bethu ngeemveliso kunye neenkonzo eziphambili.
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