●Yintoni iBerberine?
IBerberine yialkaloid yendalo ethathwe kwiingcambu, iziqu kunye namaxolo ezityalo ezahlukeneyo, ezifana neCoptis chinensis, iPhellodendron amurense kunye neBerberis vulgaris. Sesona sithako sisebenzayo seCoptis chinensis kwisiphumo se-antibacterial.
IBerberine yikristale etyheli enenaliti enencasa ekrakra. Esona sithako sikrakra kwiCoptis chinensis yiberberine hydrochloride. Le alkaloid isoquinoline isasazwe kwizityalo ezahlukeneyo zendalo. Ikhona kwiCoptis chinensis ngohlobo lwehydrochloride (berberine hydrochloride). Uphononongo lufumene ukuba le khompawundi ingasetyenziselwa ukunyanga amathumba, i-hepatitis, izifo zentliziyo, uxinzelelo lwegazi, ukudumba, usulelo lwebhaktiriya kunye nentsholongwane, isifo sohudo, isifo se-Alzheimer kunye nesifo samathambo.
● Ziziphi iiNzuzo kwiMpilo yeBerberine?
1.Antioxidant
Ngaphantsi kweemeko eziqhelekileyo, umzimba womntu ugcina ibhalansi phakathi kwe-antioxidants kunye ne-prooxidants. Uxinzelelo lwe-oxidative yinkqubo eyingozi enokuthi ibe ngumlamli obalulekileyo womonakalo wesakhiwo seseli, ngaloo ndlela ibangela izifo ezahlukeneyo ezifana nesifo senhliziyo, umhlaza, izifo ze-neurological kunye nesifo sikashukela. Ukuveliswa ngokugqithiseleyo kweentlobo ze-oxygen esebenzayo (i-ROS), ngokuqhelekileyo ngokuvuselela ngokugqithiseleyo kwe-NADPH ngama-cytokines okanye ngekhonkco lokuthutha i-electron mitochondrial kunye ne-xanthine oxidase, kunokukhokelela kuxinzelelo lwe-oxidative. Iimvavanyo zibonise ukuba i-berberine metabolites kunye ne-berberine ibonisa umsebenzi ogqwesileyo we-OH wokucoca, ophantse ulingane ne-antioxidant enamandla ye-vitamin C. Ulawulo lwe-berberine kwiigundane zesifo sikashukela lunokubeka iliso ekunyuseni komsebenzi we-SOD (superoxide dismutase) kunye nokuncipha kwe-MDA (a) isiphawuli se-lipid peroxidation) amanqanaba [1]. Iziphumo ezingaphezulu zibonisa ukuba umsebenzi wokuhlamba we-berberine unxulumene ngokusondeleyo nomsebenzi wayo we-ferrous ion chelating, kunye neqela le-C-9 le-hydroxyl ye-berberine yinxalenye ebalulekileyo.
2.Anti-ithumba
Kukho iingxelo ezininzi malunga nefuthe lokuchasa umhlaza weiberberine. Izifundo ezahlukeneyo kwiminyaka yakutshanje zibonise ukuba i-berberine ibaluleke kakhulu kunyango lwe-adjuvant yezifo zomhlaza ezinzulu ezifana nomhlaza wesibeleko, umhlaza we-endometrial, umhlaza womlomo wesibeleko, umhlaza wesifuba, umhlaza wemiphunga, umhlaza we-colorectal, umhlaza wezintso, umhlaza wesinyi kunye nomhlaza wesibeleko. [2]. I-Berberine inokuthintela ukwanda kweeseli ze-tumor ngokusebenzisana neenjongo ezahlukeneyo kunye neendlela. Inokutshintsha ukubonakaliswa kwe-oncogenes kunye ne-carcinogenesis-related genes ukufezekisa injongo yokulawula umsebenzi wee-enzymes ezinxulumene nokuthintela ukwanda.
3.Ukwehlisa iLipids zeGazi kunye noKhuseleko lweCardiovascular System
I-Berberine idlala indima ebalulekileyo kunyango lwezifo ze-cardiovascular and has a wide range of applications. I-Berberine ifezekisa injongo ye-anti-arrhythmia ngokunciphisa iziganeko ze-ventricular beats ngaphambi kwexesha kunye nokuvimbela ukuvela kwe-ventricular tachycardia. Okwesibini, i-dyslipidemia ngumngcipheko omkhulu wesifo senhliziyo, esibonakaliswa ngamanqanaba aphezulu e-cholesterol epheleleyo, i-triglycerides, kunye ne-low-density lipoprotein cholesterol (LDL), kunye nokunciphisa amanqanaba e-high-density lipoprotein (HDL), kunye ne-berberine inokugcina ngamandla ukuzinza kwezi zalathi. I-hyperlipidemia yexesha elide ingunobangela obalulekileyo wokwakheka kwe-atherosclerotic plaque. Kubikwa ukuba i-berberine ichaphazela i-LDL receptors kwi-hepatocytes ukunciphisa amanqanaba e-cholesterol e-serum kwi-hepatocytes. Akunjalo kuphela,iberberineinesiphumo esihle se-inotropic kwaye isetyenziselwe ukunyanga ukungaphumeleli kwentliziyo.
4.Yehlisa iswekile yegazi kwaye ilawula i-Endocrine
I-Diabetes mellitus (DM) yintlupheko yemetabolism ebonakaliswe ngamanqanaba aphezulu eswekile yegazi (hyperglycemia) okubangelwa ukungakwazi kweeseli ze-pancreatic B ukuvelisa i-insulin eyaneleyo, okanye ukulahlekelwa kwempendulo ye-tissue esebenzayo kwi-insulin. Umphumo we-hypoglycemic we-berberine wafunyanwa ngengozi kwi-1980 kunyango lwezigulane zesifo seswekile ezinesifo sohudo.
Izifundo ezininzi ziye zabonisa ukubaiberberineyehlisa iswekile yegazi ngezi ndlela zilandelayo:
● Inqanda i-mitochondrial glucose oxidation kwaye ivuselele i-glycolysis, emva koko ikhulise i-glucose metabolism;
● Ukunciphisa amanqanaba e-ATP ngokuthintela umsebenzi we-mitochondrial kwisibindi;
● Ivimbela umsebenzi we-DPP 4 (i-serine protease yonke indawo), ngaloo ndlela icoca iipeptide ezithile ezenza ukwandisa amanqanaba e-insulin phambi kwe-hyperglycemia.
● I-Berberine inempembelelo enenzuzo ekuphuculeni ukuxhathisa kwe-insulin kunye nokusetyenziswa kwe-glucose kwizicubu ngokunciphisa i-lipids (ingakumbi i-triglycerides) kunye ne-plasma yamazinga e-fatty acid.
Isishwankathelo
Namhlanje,iberberineinokwenziwa ngokufanelekileyo kwaye iguqulwe ngeendlela zobunjineli bekristale. Ineendleko eziphantsi kunye nobuchwepheshe obuphambili. Ngokuphuhliswa kophando lwezonyango kunye nokujula kophando lweekhemikhali, i-berberine ngokuqinisekileyo iya kubonisa iziphumo ezininzi zonyango. Kwelinye icala, i-berberine ayifumananga kuphela iziphumo ezimangalisayo kuphando lwezonyango lwemveli kwi-antibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabetic, kunye nonyango lwezifo zentliziyo kunye ne-cerebrovascular, kodwa kunye noyilo lobunjineli bekristale kunye nohlalutyo lwe-morphological. baye bafumana ingqalelo ebanzi. Ngenxa yokusebenza kwayo okubalulekileyo kunye netyhefu ephantsi kunye nemiphumo emibi, inamandla amakhulu kwisicelo seklinikhi kwaye inethemba elibanzi. Ngophuhliso lwebhayoloji yeseli, indlela ye-pharmacological ye-berberine iya kucaciswa ukusuka kwinqanaba leselula kunye nakwinqanaba le-molecular kunye nethagethi, ukubonelela ngesiseko sethiyori ngakumbi kwisicelo sayo seklinikhi.
● Unikezelo ENTSHABerberine/Liposomal Berberine Powder/Capsules/Tablets
Ixesha lokuposa: Oct-28-2024
