Ekufunyanweni komhlaba, izazinzulu zenze inkqubela phambili enkulu ekuqondeni indima ye-superoxide dismutase.SOD) ekugcineni impilo yeselula.SODyi-enzayim ebalulekileyo edlala indima ebalulekileyo ekukhuseleni iiseli kuxinzelelo lwe-oxidative ngokuthoba iiradicals zasimahla eziyingozi. Oku kufunyaniswayo kunamandla okuguqula unyango lwezifo ezahlukeneyo ezinxulumene nomonakalo we-oxidative, njengomhlaza, ukuphazamiseka kwe-neurodeergenerative, kunye neemeko ezinxulumene nokuguga.
Ukuphonononga iisiphumoyeI-Superoxide Dismutase (SOD) :
Abaphandi kudala bekwazi ukubaluleka kweSODkwimpilo yeselula, kodwa iindlela ezichanekileyo esebenza ngazo zihlala zinzima. Nangona kunjalo, uphononongo lwakutsha nje olupapashwe kwiphephancwadi loNxibelelwano lweNdalo luye lwabonisa ukukhanya okutsha ngalo mbandela. Uphononongo ludize ukubaSODayigcini nje ngokutshabalalisa i-superoxide radicals eyingozi kuphela kodwa ilawula ukubonakaliswa kwemfuza echaphazelekayo kwiindlela zokukhusela iiseli, ngaloo ndlela iphucula amandla eseli okumelana noxinzelelo lwe-oxidative.
Iziphumo zolu phando zifikelela kude, njengoko zivula amathuba amatsha okuphuhlisa unyango olujoliswe kuyo kwiimeko ezinxulumene nomonakalo we-oxidative. Ngokufumana ukuqonda okunzulu malunga nendlelaSODImisebenzi kumgangatho wemolekyuli, izazinzulu ngoku zinokuphonononga iindlela ezintsha zokulungelelanisa umsebenzi wayo kwaye zinokunciphisa ifuthe loxinzelelo lwe-oxidative ekusebenzeni kweselula. Oku kunokukhokelela kuphuhliso lonyango olusebenzayo ngakumbi kuluhlu olubanzi lwezifo, enika ithemba kwizigidi zabaguli kwihlabathi liphela.
Ngaphezu koko, iziphumo zophando zikwazi ukwazisa ukuphuhliswa kwezicwangciso zokukhusela ukugcina impilo yeselula kunye nokunciphisa inkqubo yokuguga. Ngokusebenzisa iziphumo ezikhuselayo zeSOD, abaphandi banokukwazi ukuphuhlisa iindlela zokungenelela ezinokunceda abantu bagcine umsebenzi ophezulu weselula njengoko bekhula, ukunciphisa umngcipheko wezifo ezinxulumene neminyaka kunye nokukhuthaza inhlalakahle jikelele.
Ukuqukumbela, impumelelo yakutshanje ekuqondeni indima yeSOD kwimpilo yeselula imele inkqubela phambili ebalulekileyo kwicandelo lophando lwebhayoloji. Ngokutyhila iindlela ezintsonkothileyoSOD ikhusela iiseli emonakalweni we-oxidative, izazinzulu ziye zavula indlela yokuphuhliswa kweendlela ezintsha zonyango kunye nokungenelela kokuthintela. Oku kufunyanisiweyo kunesithembiso esikhulu sokuphucula unyango kunye nokulawulwa kwezifo ezinxulumene noxinzelelo lwe-oxidative, enika ithemba ngekamva elinempilo kubantu kwihlabathi liphela.
Ixesha lokuposa: Jul-25-2024
