Kule minyaka yangoku,NMN, esele idumile kwihlabathi jikelele, ithathe ukhangelo olushushu kakhulu. Wazi kangakanani nge-NMN? Namhlanje, siza kugxila ekuziseni i-NMN, ethandwa ngumntu wonke.
● YintoniNMN?
I-NMN ibizwa ngokuba yi-β-Nicotinamide Mononucleotide, okanye i-NMN ngokufutshane. I-NMN inee-diastereomers ezimbini: α kunye no-β. Uphononongo lufumene ukuba kuphela uhlobo lwe-β-NMN olunomsebenzi webhayoloji. Ngokwesakhiwo, imolekyuli yenziwe yi-nicotinamide, i-ribose kunye ne-phosphate.
I-NMN yenye yezandulela ze-NAD+. Ngamanye amazwi, isiphumo esingundoqo se-NMN siphunyezwa ngokuguqulelwa kwi-NAD+. Njengoko sikhula, inqanaba le-NAD + emzimbeni womntu liyehla ngokuthe ngcembe.
Kwi-Aging Biology Research Compilation ka-2018, iindlela ezimbini eziphambili zokuguga kwabantu zashwankathelwa:
1. Umonakalo obangelwa uxinzelelo lwe-oxidative (iimpawu zibonakala njengezifo ezahlukeneyo)
2. Ukunciphisa amanqanaba e-NAD + kwiiseli
Inani elikhulu leempumelelo kwizifundo kwi-NAD+ yophando lokulwa nokuguga ngoososayensi abaphambili behlabathi baxhasa isigqibo sokuba ukonyuka kwamanqanaba e-NAD+ kunokuphucula umgangatho wezempilo kwiinkalo ezininzi kunye nokulibazisa ukwaluphala.
● Yintoni iiNzuzo zeMpilo yazoNMN?
1.Yandisa umxholo we-NAD +
I-NAD + yinto ebalulekileyo yokugcina ukusebenza komzimba. Ikhona kuzo zonke iiseli kwaye ithatha inxaxheba kumawaka eempendulo zefiziyoloji emzimbeni. Ngaphezulu kwe-500 yeeenzymes emzimbeni womntu zifuna i-NAD +.
Ukusuka kumzobo, sinokubona ukuba izibonelelo zokuncedisa i-NAD + kumalungu ahlukeneyo ziquka ukuphucula impilo yengqondo kunye nenkqubo ye-nervous, isibindi kunye nezintso, imithambo yegazi, intliziyo, izicubu ze-lymphatic, amalungu okuzala, i-pancreas, izicubu ze-adipose, kunye nezihlunu.
Kwi-2013, iqela lophando elikhokelwa nguNjingalwazi uDavid Sinclair we-Harvard Medical School libonakalise ngeemvavanyo ukuba emva kokulawulwa komlomo kwe-NMN kwiveki enye, inqanaba le-NAD + kwiigundane zeenyanga ze-22 liye landa, kunye nezalathi eziphambili ze-biochemical ezinxulumene ne-mitochondrial homeostasis kunye ne-2013. umsebenzi wemisipha wabuyiselwa kwimeko yeempuku ezincinci ezilingana neenyanga ze-6 ubudala.
2. Sebenzisa iiprotheyini ze-SIR
Uphando kwiminyaka eyi-20 edlulileyo lufumene ukuba i-Sirtuins idlala indima enkulu yokulawula phantse yonke imisebenzi yeeseli, echaphazela iinkqubo ze-physiological ezifana nokuvutha, ukukhula kweeseli, isigqi se-circadian, i-metabolism yamandla, umsebenzi we-neuronal kunye nokuxhatshazwa koxinzelelo.
Ii-Sirtuins zihlala zibizwa ngokuba yintsapho yeprotheyini yokuphila ixesha elide, eyintsapho ye-NAD + -exhomekeke kwiiprotheni ze-deacetylase.
Ngo-2019, uNjingalwazi Kane AE weSebe leGenetics kwisikolo saseHarvard Medical kunye nabanye bafumanisa ukubaNMNsisandulela esibalulekileyo sokwenziwa kweNAD + emzimbeni. Emva kokuba i-NMN ikhulise inqanaba le-NAD + kwiiseli, ezininzi zeempembelelo zayo ezintle (ezifana nokuphucula imetabolism, ukukhusela inkqubo ye-cardiovascular system, njl.) ifezekiswa ngokuvula i-Sirtuins.
3. Lungisa umonakalo weDNA
Ukongeza kokuchaphazela umsebenzi we-Sirtuins, inqanaba le-NAD + emzimbeni likwayinxalenye ebalulekileyo ye-DNA yokulungisa i-enzyme PARPs (i-poly ADP-ribose polymerase).
4. Ukukhuthaza imetabolism
I-Metabolism yingqokelela yeempendulo zeekhemikhali ezigcina ubomi kwizinto eziphilayo, ezivumela ukuba zikhule kwaye zivelise kwakhona, zigcine ukwakheka kwazo, kwaye ziphendule kwimo engqongileyo. I-Metabolism yinkqubo apho izinto eziphilayo zihlala zitshintshiselana ngezinto kunye namandla. Nje ukuba iyeke, ubomi bento ephilayo buya kuphela. UNjingalwazi Anthony weDyunivesithi yaseCalifornia kunye neqela lakhe bafumanise ukuba i-NAD+ imetabolism iye yaba lunyango olunokubakho lokuphucula izifo ezinxulumene nokwaluphala kunye nokwandisa impilo yabantu kunye nobomi.
5. Ukukhuthaza ukuvuselelwa kwemithambo yegazi kunye nokugcina ukuqina kwemithambo yegazi
Imithambo yegazi zizicubu eziyimfuneko zokuhambisa ioksijini kunye nezondlo, ukusetyenzwa kwekhabhon diokside kunye neemetabolites, kunye nokulawula ubushushu bomzimba. Njengoko sikhula, imithwalo yegazi ngokuthe ngcembe ilahlekelwa ukuguquguquka kwayo, ibe nzima, ilukhuni, kwaye incinci, ibangela "i-arteriosclerosis."
Ngo-2020, uphando olwenziwa ngabafundi abathile be-PhD abavela kwiYunivesithi yeTekhnoloji yaseZhejiang e-China, kuquka ne-Sh, yafumanisa ukuba emva kokulawulwa komlomo.NMNukuya kwiimpuku ezidandathekileyo, iimpawu zokudakumba zathotywa ngokunyusa amanqanaba e-NAD+, ukusebenzisa i-Sirtuin 3, kunye nokuphucula i-mitochondrial energy metabolism kwi-hippocampus kunye neeseli zesibindi zobuchopho beempuku.
6. Khusela impilo yentliziyo
Intliziyo lelona lungu libalulekileyo emzimbeni womntu kwaye ibalulekile ekugcineni ukusebenza kwentliziyo. Ukuhla kumanqanaba e-NAD + kunxulumene ne-pathogenesis yezifo ezahlukeneyo zentliziyo. Inani elikhulu lezifundo ezisisiseko nazo zibonise ukuba ukongeza i-coenzyme ndiyakwazi ukuzuza iimodeli zesifo senhliziyo.
7. Gcina impilo yengqondo
Ukungasebenzi kakuhle kwe-neurovascular kunokubangela ukonakala kwangaphambili kwemithambo kunye ne-neurodeergenerative cognitive. Ukugcina umsebenzi we-neurovascular kubalulekile ekuthinteleni izifo ze-neurodeergenerative.
Imiba esemngciphekweni efana nesifo seswekile, i-hypertension ye-midlife, ukutyeba kwe-midlife, ukungasebenzi komzimba kunye nokutshaya zonke zinxulunyaniswa nesifo se-vascular dementia kunye nesifo se-Alzheimer.
8. Ukuphucula uvakalelo lwe-insulin
Ubuzwe be-insulin buchaza inqanaba lokunganyangeki kwe-insulin. Okukhona ukuncipha kobuntununtunu kwi-insulin, kokukhona kusezantsi iqondo lokuqhekeka kweswekile.
Ukumelana ne-insulin kubhekiselele ekunciphiseni uvakalelo lwamalungu ekujoliswe kuwo e-insulin kwisenzo se-insulin, oko kukuthi, imeko apho idosi eqhelekileyo ye-insulin ivelisa isiphumo esingaphantsi kunesiqhelo sebhayoloji. Unobangela oyintloko wohlobo lwe-2 yeswekile kukukhuselwa kwe-insulin ephantsi kunye novelwano oluphantsi lwe-insulin.
NMN, njengesongezelelo, kunokunceda ukuphucula ubuntununtunu be-insulin ngokunyusa amanqanaba e-NAD +, ukulawula iindlela ze-metabolic, kunye nokuphucula ukusebenza kwe-mitochondrial.
9. Uncedo ekulawuleni ubunzima
Ubunzima abuchaphazeli kuphela umgangatho wobomi kunye nempilo, kodwa bubuye bube yinto ebangela ezinye izifo ezingapheliyo. Uphononongo lubonise ukuba i-NAD precursor β-nicotinamide mononucleotide (NMN) inokuguqula ezinye zeempembelelo ezimbi zokutya okunamafutha aphezulu (HFD).
Ngo-2017, uNjingalwazi uDavid Sinclair weSikolo sezoNyango saseHarvard kunye neqela lophando elivela kwiSikolo sezoNyango sase-Australia bathelekisa iimpuku ezibhityileyo ezizilolonga kwi-treadmill iiveki ze-9 okanye zitofwe nge-NMN yonke imihla ngeentsuku ze-18. Iziphumo zibonise ukuba i-NMN ibonakala inefuthe elinamandla kwi-metabolism yamafutha esibindi kunye ne-synthesis kunokuzivocavoca.
●Ukhuseleko lweNMN
I-NMN ithathwa njengekhuselekile kuvavanyo lwezilwanyana, kwaye iziphumo ziyakhuthaza. Iyonke i-19 yolingo lweklinikhi yabantu sele iqalisiwe, apho i-2 ipapashe iziphumo zovavanyo.
Iqela lophando elivela kwiYunivesithi yaseWashington School of Medicine eSt. Louis lipapashe inqaku kwiphephancwadi eliphezulu lezenzululwazi "Isayensi", ebonisa iziphumo zovavanyo lokuqala lwezonyango lomntu, eqinisekisa inzuzo ye-metabolic ye-NMN kumzimba womntu.
● ENTSHA GREEN Nikeza ngeNMN Powder/Capsules/Liposomal NMN
Ixesha lokuposa: Oct-15-2024
