Yintoni iResveratrol?
I-Resveratrol yikhompawundi yendalo efumaneka kwizityalo ezithile, iziqhamo, kunye newayini ebomvu. Yeqela leekhompawundi ezibizwa ngokuba yi-polyphenols, ezisebenza njenge-antioxidants kwaye zaziwa ngeenzuzo zazo zempilo ezinokubakhona. IResveratrol ininzi kakhulu eluswini lomdiliya obomvu kwaye ibingumxholo wezifundo ezininzi ngenxa yeziphumo zayo ezinokuthi zibekho kwimiba eyahlukeneyo yempilo.
Olunye uphando lucebisa ukuba i-resveratrol inokuba neenzuzo ezinokuthi zibekho kwimpilo yentliziyo, njengoko inokunceda ukuxhasa imithambo yegazi enempilo kunye nokujikeleza. Ukongezelela, ifundwe ngeempawu zayo ezichasayo kunye ne-antioxidant, ezinokuthi zibe nefuthe kwimpilo yonke kunye neenkqubo zokuguga.
I-Resveratrol iphandwe ngendima yayo enokubakho ekuxhaseni impilo yengqondo kunye nokusebenza kwengqondo, kunye neziphumo zayo kwimetabolism kunye neenzuzo ezinokubakho zokulawula ubunzima.
IiPropati zePhysical and Chemical of Resveratrol
I-Resveratrol (i-3-4'-5-trihydroxystilbene) i-non-flavonoid polyphenol compound. Igama layo lekhemikhali yi-3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-trihydroxystilbene), ifomula yayo ye-molecular yi-C14H12O3, kunye nobunzima bayo be-molecular yi-228.25.
I-resveratrol ecocekileyo ibonakala imhlophe ukuya kumgubo ophuzi okhanyayo, ongenavumba, onganyibilikiyo emanzini, kwaye kulula ukunyibilika kwii-solvents eziphilayo ezifana ne-ether, i-chloroform, i-methanol, i-ethanol, i-acetone, kunye ne-ethyl acetate. Indawo yokunyibilika yi-253-255 ° C, kwaye iqondo lobushushu le-sublimation yi-261 ° C. Inokujika ibebomvu ngezisombululo zealkaline ezifana namanzi ammonia, kwaye inokusabela ngeferric chloride-potassium ferrocyanide. Le propati ingasetyenziselwa ukuchonga i-resveratrol.
I-resveratrol yendalo inezakhiwo ezimbini, i-cis kunye ne-trans. Ibakho ikakhulu kutshintsho kwindalo. Izakhiwo ezibini zinokudibaniswa ne-glucose ukwenza i-cis kunye ne-trans resveratrol glycosides. I-Cis- kunye ne-trans-resveratrol glycosides inokukhulula i-resveratrol phantsi kwesenzo se-glycosidase emathunjini. Ngaphantsi kokukhanya kwe-ultraviolet, i-trans-resveratrol inokuguqulwa ibe yi-cis-isomers.
Indlela Yokulungiselela
Indlela yokutsalwa kwezityalo zendalo
Iidiliya, i-knotweed kunye ne-peanuts zisetyenziswa njengemathiriyeli ekrwada ukukhupha kunye nokwahlula i-resveratrol ekrwada, kwaye emva koko ihlanjululwe. Itekhnoloji eziphambili zokutsalwa ngokukrwada ziquka ukutsalwa kwe-organic solvent, ukutsalwa kwealkaline kunye nokutsalwa kwe-enzyme. Iindlela ezintsha ezifana ne-microwave-assisted extraction, i-CO2 ye-supercritical extraction kunye ne-ultrasonic-assisted extraction nayo isetyenziswa. Injongo yokucoca ikakhulu ukwahlula i-cis- kunye ne-trans-isomers ye-resveratrol kunye ne-resveratrol kwi-resveratrol ekrwada ukufumana i-trans-resveratrol. Iindlela zokucoca eziqhelekileyo zibandakanya ichromatography, ikholomu yejeli yesilica chromatography, umaleko obhityileyo wechromatography, ukusebenza okuphezulu kwechromatography yolwelo, njl.
Indlela yokudibanisa
Ukusukela umxholo wei-resveratrolkwizityalo ziphantsi kakhulu kwaye iindleko zokukhutshwa ziphezulu, ukusetyenziswa kweekhemikhali, ibhayoloji, ubunjineli bezofuzo kunye nezinye iindlela zokufumana i-resveratrol ibe yindlela efunekayo kwinkqubo yophuhliso. I-Perkin reaction, i-Hech reaction, kunye ne-Witting-Hormer reaction ziyindlela ekhulileyo yeekhemikhali zokudibanisa i-resveratrol, kunye nezivuno ze-55.2%, i-70%, kunye ne-35.7% ngokulandelanayo. Ubuchwephesha bobunjineli bemfuza busetyenziselwa ukulawula okanye ukuphucula indlela ye-biosynthesis ye-resveratrol ukufumana iintlobo zezityalo ezivelisa isivuno esikhulu; iindlela ezifana nokusebenzisa i-mutagenesis ukukhetha imigca yeeseli eziphezulu zemveliso inokunyusa isivuno se-resveratrol ngamaxesha angama-1.5 ~ 3.0.
Yintoni Inzuzo YaResveratrol?
I-Resveratrol ibe ngumxholo wophando ngenxa yeenzuzo zayo zempilo. Ezinye zezibonelelo ezinokubakho ze-resveratrol ziquka:
1.Ukuchasa ukuguga
Kwi-2003, unjingalwazi weYunivesithi yaseHarvard uDavid Sinclair kunye neqela lakhe bafumanisa ukuba i-resveratrol inokusebenzisa i-acetylase kwaye yandise ixesha lokuphila kweyeast, eyabangela ukunyuka kophando lokuguga kwi-resveratrol. Howitz et al. ifumene ukuba i-resveratrol inokusebenza njenge-activator enamandla kakhulu yomgaqo wolwazi oluthulile i-2 homolog1 (SIRT1), inokufanisa impendulo yokuguga yokunciphisa ikhalori (CR), kwaye ithathe inxaxheba kulawulo lomyinge wobomi bezinto eziphilayo. . I-CR yi-inducer enamandla ye-SIRT1 kwaye inokunyusa ukubonakaliswa kwe-SIRT1 kwizitho kunye nezicubu ezifana nengqondo, intliziyo, amathumbu, izintso, imisipha kunye namafutha. I-CR inokubangela utshintsho lomzimba olulibazisa ukuguga kunye nokwandisa ixesha lokuphila, eyona nto ibalulekileyo inokwandiswa ngama-50%. . Izifundo ziqinisekisile ukuba i-resveratrol inokwandisa ixesha lokuphila kweyeast, nematodes, iimpukane zeziqhamo kunye neentlanzi ezincinci.
2.Anti-ithumba, anti-umhlaza
I-Resveratrol ineziphumo ezibalulekileyo zokuthintela kwiiseli ezahlukeneyo zethumba ezifana ne-hepatocellular carcinoma, umhlaza wamabele, umhlaza wekoloni, umhlaza wesisu, kunye ne-leukemia. Abanye abaphengululi baye baqinisekisa ukuba i-resveratrol inempembelelo enkulu yokuthintela kwiiseli ze-melanoma ngokusebenzisa indlela ye-MTT kunye nokuhamba kwe-cytometry.
Kukho iingxelo zokuba i-resveratrol inokuphucula i-radiotherapy yomhlaza kwaye ithintele ngokufanelekileyo iziphumo zeeseli zomhlaza. Kodwa ukuza kuthi ga ngoku, ngenxa yobunzima be-resveratrol ye-anti-tumor mechanism, abaphandi abakafiki kwisivumelwano malunga nendlela yokusebenza kwayo.
3.Thintela kunye nokunyanga isifo se-cardiovascular
Izifundo ze-Epidemiological ziye zafumanisa ukuba "i-French paradox" into yokuba abantu baseFransi badla isixa esikhulu samanqatha imihla ngemihla, kodwa iziganeko kunye nokufa kwezifo ze-cardiovascular kuphantsi kakhulu kunamanye amazwe aseYurophu. Le nto inokunxulunyaniswa nokusela kwabo isixa esikhulu sewayini yonke imihla. , kunye ne-resveratrol ingaba yinto ephambili yokukhusela esebenzayo. Uphando lubonisa ukuba i-resveratrol inokulawula amanqanaba e-cholesterol yegazi ngokubopha kwi-estrogen receptors emzimbeni womntu, inqanda iiplatelet ekwenzeni amahlwili egazi kunye nokunamathela kwiindonga zemithambo yegazi, ngaloo ndlela inqanda kwaye inciphisa ukwenzeka kunye nokuphuhliswa kwesifo senhliziyo, kunye nokunciphisa umngcipheko isifo sentliziyo emzimbeni womntu. Umngcipheko wesifo se-vascular.
4.Inkxaso yeAntioxidant:Resveratrolisebenza njenge-antioxidant, inceda ukukhusela iiseli kumonakalo we-oxidative obangelwa yi-radicals yamahhala. Oku kunokuba nefuthe kwimpilo jikelele kunye neenkqubo zokuguga.
6. Impilo yengqondo: Uphando luhlolisise indima enokubakho ye-resveratrol ekuxhaseni impilo yengqondo kunye nokusebenza kwengqondo, kunye nezifundo ezithile ezibonisa iimpawu ze-neuroprotective.
I-7.I-Metabolism kunye noLawulo loMzimba: I-Resveratrol iphandiwe ngenxa yemiphumo enokubakho kwi-metabolism kunye nendima yayo ekuxhaseni ukulawula ubunzima obunempilo.
Yintoni Izicelo ZeResveratrol?
I-Resveratrol inezicelo ezahlukeneyo kwaye isetyenziswa kwiinkalo ezahlukeneyo ngenxa yeenzuzo zayo zempilo. Ezinye zezicelo ze-resveratrol ziquka:
1. Izongezo zokutya: I-Resveratrol isetyenziswa ngokuqhelekileyo kwizongezelelo zokutya, zihlala zithengiswa ngenxa yezinto ezinokuthi zibe ne-antioxidant kunye ne-anti-aging properties.
2. IiMveliso ze-Skincare: I-Resveratrol ifakwe kwezinye iimveliso ze-skincare ngenxa yeempawu zayo ze-antioxidant, ezinokunceda ukukhusela ulusu kumonakalo wokusingqongileyo kunye nokuxhasa impilo yonke yesikhumba.
3. Ukutya okuSebenzayo kunye neZiselo: I-Resveratrol ngamanye amaxesha yongezwa kukutya okusebenzayo kunye neziphuzo, ezifana neziphuzo zamandla kunye nemveliso yokutya ejoliswe kwimpilo, ukubonelela ngezibonelelo zempilo.
4. UPhando kunye noPhuhliso: I-Resveratrol iyaqhubeka ibe ngumxholo wophando lwezesayensi, kunye nezifundo eziqhubekayo zihlola izicelo ezinokuthi zisebenzise kwiimeko ezahlukeneyo zempilo kunye nemiphumo yokuguga, imetabolism, kunye nokuphila kakuhle.
Yintoni Icala elisezantsi leResveratrol?
Ngelixa i-resveratrol ifundwe ngezibonelelo zayo zempilo, kubalulekile ukuqwalasela ukwehla okanye imida ehambelana nokusetyenziswa kwayo. Ezinye izinto eziqwalaselwayo malunga nezantsi kwe-resveratrol ziquka:
1. I-Bioavailability elinganiselweyo: I-Resveratrol ine-bioavailability ephantsi, oku kuthetha ukuba umzimba awukwazi ukuwufunxa kwaye uwusebenzise ngokufanelekileyo xa uthathwa ngomlomo. Oku kunokuchaphazela ukusebenza kwayo ekuveliseni iziphumo ezifunwayo zempilo.
2. Ukunqongophala koMgangatho: Umgangatho kunye noxinzelelo lwezongezelelo ze-resveratrol zinokuhluka, kwaye kukho ukungabikho komgangatho ekuvelisweni kwezi zongezo. Oku kunokwenza kube nzima kubathengi ukumisela idosi efanelekileyo kunye nomgangatho wemveliso.
3. Ukusebenzisana okunokwenzeka: I-Resveratrol inokusebenzisana namayeza athile okanye iimeko zempilo. Kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokusebenzisa i-resveratrol, ngakumbi ukuba uthatha amanye amayeza okanye unenkxalabo ethile yezempilo.
4. Ukulinganiselwa koPhando: Nangona ezinye izifundo zibonise iziphumo ezithembisayo, uphando olongezelelweyo lufunekayo ukuze uqonde ngokupheleleyo iziphumo zexesha elide, idosi efanelekileyo, kunye neengozi ezinokuthi zidibene ne-resveratrol supplementation.
Njengaso nasiphi na isongezelelo, kuyacetyiswa ukuba usebenzise i-resveratrol ngononophelo kwaye phantsi kwesikhokelo sokhathalelo lwezempilo, ngakumbi ukuba unenkxalabo ethile yezempilo okanye uthatha amanye amayeza.
Imibuzo eyeleleneyo onokuthi ubenomdla kuyo:
Ngubani ofanele amphephei-resveratrol?
Abantu abathile kufuneka balumke okanye baphephe i-resveratrol, ngakumbi kwifomu yokongeza. Kuyacetyiswa ukuba la maqela alandelayo adibane nengcali yezempilo phambi kokusebenzisa i-resveratrol:
1. Abasetyhini abakhulelweyo okanye abancancisayo: Ngenxa yophando olunyiniweyo malunga neziphumo ze-resveratrol ngexesha lokukhulelwa kunye nokuncancisa, kuyacetyiswa kubasetyhini abakhulelweyo okanye abancancisayo ukuba bafune isikhokelo kukhathalelo lwezempilo ngaphambi kokusebenzisa izongezo ze-resveratrol.
2. Abantu abaThatha i-Blood Thinners: I-Resveratrol inokuba neempawu ze-anticoagulant ezithambileyo, ngoko ke abantu abathatha amayeza okunciphisa igazi kufuneka badibane nochwepheshe bezempilo ngaphambi kokusebenzisa i-resveratrol ukuphepha ukusebenzisana okunokwenzeka.
3. Abo baneeMeko ze-Hormone-Sensitive Conditions: I-Resveratrol ifundwe ngemiphumo enokubakho ekulawuleni i-hormone, ngoko ke abantu abaneemeko ze-hormone-sensitive okanye abo bafumana unyango lwe-hormone kufuneka basebenzise i-resveratrol ngokuqaphela kwaye phantsi kweliso lonyango.
4. Abantu abaneeMeko zesibindi: Olunye uphando lucebise ukuba amanani aphezulu e-resveratrol anokuba nemiphumo kwisibindi. Abantu abaneemeko zesibindi okanye abo bathatha amayeza achaphazela isibindi kufuneka basebenzise i-resveratrol ngononophelo kwaye phantsi kweliso lonyango.
Njengaso nasiphi na isongezelelo, kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokuba usebenzise i-resveratrol, ngakumbi ukuba unenkxalabo ethile yezempilo, uthatha amayeza, okanye uneemeko zempilo eziphantsi.
Yenza ntoni i-resveratrol eluswini?
I-Resveratrol kukholelwa ukuba ibonelela ngeengenelo ezininzi zolusu, ezikhokelele ekufakweni kwayo kwiimveliso zokhathalelo lwesikhumba. Ezinye zeziphumo ze-resveratrol eluswini zinokubandakanya:
1. Ukukhuselwa kwe-Antioxidant: I-Resveratrol isebenza njenge-antioxidant, inceda ukunciphisa i-radicals yamahhala kunye nokunciphisa uxinzelelo lwe-oxidative esikhumbeni. Oku kunokukhusela ulusu kumonakalo wokusingqongileyo, njengemitha ye-UV kunye nongcoliseko.
2. Iimpawu ezichasene nokuguga: I-Resveratrol icingelwa ukuba ineempembelelo zokuguga, njengoko inokunceda ukunciphisa ukubonakala kwemigca emihle kunye nemibimbi, ukuphucula ukuqina kwesikhumba, kunye nokuxhasa impilo yonke yesikhumba.
3. Iimpembelelo ezichasene nokudumba: I-Resveratrol ifundwe ngeempawu zayo ezichasene nokudumba, ezinokunceda ukuthomalalisa nokuthomalalisa ulusu, ngakumbi kubantu abanolusu olubuthathaka okanye olusebenzayo.
4. Ukukhanya kwesikhumba: Olunye uphando lubonisa ukuba i-resveratrol inokufaka isandla ekukhanyeni kwesikhumba kunye nokuhlwa kwethoni yesikhumba, inokunciphisa ukubonakala kwe-hyperpigmentation.
Kukuphi ukutya okuphezulu kwi-resveratrol?
Ukutya okuphezulu kwi-resveratrol kubandakanya:
1. Iidiliya eziBomvu: I-Resveratrol ininzi kakhulu kwisikhumba seediliya ezibomvu, okwenza iwayini ebomvu ibe ngumthombo we-resveratrol. Nangona kunjalo, kubalulekile ukusela utywala ngokumodareyitha, kwaye eminye imithombo ye-resveratrol inokukhethwa kubantu abangaseli.
2. Amandongomane: Iindidi ezithile zamandongomane, ngakumbi ulusu lwamandongomane, zinezixa eziphawulekayo ze-resveratrol.
3. I-Blueberries: I-Blueberries iyaziwa ngokuba yi-antioxidant content, kwaye iqulethe i-resveratrol, nangona ixabiso elincinci xa kuthelekiswa neidiliya ezibomvu kunye namantongomane.
4. I-Cranberries: I-Cranberries enye imvelaphi ye-resveratrol, inika inani elincinci lale khompawundi.
5. I-Chocolate Emnyama: Ezinye iintlobo zetshokolethi emnyama ziqulethe i-resveratrol, enika indlela emnandi yokubandakanya le khompawundi ekudleni.
Ngaba kulungile ukuthatha i-resveratrol yonke imihla?
Isigqibo sokuthatha i-resveratrol yonke imihla kufuneka senziwe ngokubonisana nochwepheshe bezempilo, ngakumbi ukuba ucinga nge-resveratrol supplementation. Nangona i-resveratrol ngokuqhelekileyo ithathwa njengekhuselekile xa isetyenziswe kwiimali eziqhelekileyo ezifumaneka kukutya, ukhuseleko kunye neenzuzo ezinokuthi zenzeke kwi-resveratrol supplementation yemihla ngemihla zinokuhluka ngokusekelwe kwimeko yempilo yomntu, iimeko zonyango ezikhoyo, kunye namanye amayeza athathwayo.
Ngaba i-resveratrol inetyhefu esibindini?
I-Resveratrol ifundwe ngeziphumo zayo ezinokubakho kwisibindi, kwaye ngelixa ngokuqhelekileyo ithathwa njengekhuselekile xa idliwe kwiimali eziqhelekileyo ezifunyenwe kukutya, kukho ubungqina obubonisa ukuba iidosi eziphezulu ze-resveratrol zinokuba nemiphumo kwisibindi. Olunye uphando lubonise ukuba idosi ephezulu ye-resveratrol inokukhokelela kwityhefu yesibindi kwiimeko ezithile.
Kubalulekile ukuqaphela ukuba uphando malunga nesi sihloko luyaqhubeka, kwaye ukubakho kwetyhefu yesibindi kunokuphenjelelwa zizinto ezifana nedosi, ixesha lokusetyenziswa, kunye neemeko zempilo zomntu ngamnye. Njengaso nasiphi na isongezelelo, kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokuba usebenzise i-resveratrol, ngakumbi ukuba unenkxalabo ethile yezempilo okanye uthatha amanye amayeza anokuchaphazela ukusebenza kwesibindi.
Ngaba i-resveratrol ayilunganga kwizintso?
Kukho ubungqina obuncinane bokucebisa ukuba i-resveratrol imbi kwizintso. Nangona kunjalo, njengaso nasiphi na isongezelelo, kubalulekile ukujongana nokusetyenziswa kwayo ngononophelo, ngakumbi ukuba uneemeko zezintso okanye uthatha amayeza anokuchaphazela ukusebenza kwezintso. Kuyacetyiswa ukuba udibane nengcali yokhathalelo lwempilo ukufumanisa ukuba i-resveratrol supplementation ifanelekile na kwiimfuno zakho zempilo, ngakumbi ukuba unenkxalabo malunga nefuthe layo kwimpilo yezintso.
Yintoni ongadibanisi nayoi-resveratrol?
Xa ucinga nge-resveratrol supplementation, kubalulekile ukuba uqaphele ukusebenzisana okunokwenzeka kunye nezinye izinto. Ezinye izinto eziqwalaselwayo malunga nokuba ungaxubani ne-resveratrol ziquka:
1. Amayeza okunciphisa igazi: I-Resveratrol inokuba neempawu ezinqabileyo ze-anticoagulant, ngoko ke kubalulekile ukusebenzisa isilumkiso xa uthatha i-resveratrol kunye neyeza zokunciphisa igazi, njengoko kunokunyusa umngcipheko wokuphuma kwegazi.
2. Ezinye izongezo ze-Antioxidant: Ngelixa i-antioxidants iluncedo ngokubanzi, ukuthatha iidosi eziphezulu ze-antioxidant supplements ngaxeshanye kunokuba nemiphumo engalindelekanga. Kuyacetyiswa ukuba udibane nengcali yezempilo ngaphambi kokudibanisa i-resveratrol kunye nezinye izongezo ze-antioxidant.
3. Amachiza athile: I-Resveratrol inokusebenzisana namayeza athile, kubandakanywa ne-metabolized ngesibindi. Kubalulekile ukuxoxa ngonxibelelwano olunokubakho kunye nengcali yezempilo, ngakumbi ukuba usebenzisa amanye amayeza.
Njengaso nasiphi na isongezelelo, kubalulekile ukufuna isikhokelo kwigcisa lokhathalelo lwempilo ukumisela eyona ndlela ifanelekileyo yokusetyenziswa kwe-resveratrol esekwe kwimeko yempilo yomntu kunye nokusebenzisana okunokwenzeka nezinye izinto.
Ndingasebenzisa i-vitamin C kunye ne-resveratrol?
Ewe, ungasebenzisa ngokubanzi i-vitamin C kunye ne-resveratrol. Ngapha koko, uphando oluthile lucebisa ukuba ukudibanisa i-resveratrol kunye ne-vitamin C kunokuphucula iziphumo ze-antioxidant yazo zombini iikhompawundi. I-Vitamin C yi-antioxidant eyaziwayo enokuthi incedise izibonelelo ezinokubakho ze-resveratrol. Nangona kunjalo, njengakuyo nayiphi na indibaniselwano yezongezelelo, kuyacetyiswa ukuba udibane nengcali yezempilo ukuze uqinisekise ukuba indibaniselwano ifanelekile kwiimfuno zakho zempilo kwaye uxoxe ngayo nayiphi na intsebenziswano enokubakho okanye iingqalelo.
Ixesha lokuposa: Sep-09-2024
