• Yintoni iPQQ ?
I-PQQ, igama elipheleleyo yi-pyrroloquinoline quinone. Njenge-coenzyme Q10, i-PQQ ikwayi-coenzyme ye-reductase. Kwintsimi yezongezo zokutya, ngokuqhelekileyo kubonakala njengedosi enye (ngendlela yetyuwa ye-disodium) okanye kwifom yemveliso edibeneyo ne-Q10.
Imveliso yendalo ye-PQQ iphantsi kakhulu. Ikho kumhlaba kunye ne-microorganisms, izityalo kunye nezicubu zezilwanyana, ezifana neti, i-natto, i-kiwifruit, kunye ne-PQQ ikhona kwizicubu zomntu.
PQQinemisebenzi emininzi yefiziyoloji. Inokukhuthaza i-mitochondria entsha kwiiseli (i-mitochondria zibizwa ngokuba "zizityalo zokucubungula amandla kwiiseli"), ukwenzela ukuba isantya se-cell cell synthesis singanyuswa kakhulu. Ukongeza, i-PQQ iqinisekisiwe kwizifundo zezilwanyana kunye nabantu ukuphucula ukulala, amanqanaba asezantsi e-cholesterol, ukunciphisa uxinzelelo lwe-oxidative, ukwandisa ubomi, ukukhuthaza ukusebenza kwengqondo kunye nokunciphisa ukudumba.
Kwi-2017, iqela lophando elenziwe nguNjingalwazi uHiroyuki Sasakura kunye nabanye abavela kwiYunivesithi yaseNagoya eJapan bapapashe iziphumo zabo zophando kwiphephancwadi elithi "JOURNAL OF CELL SCIENCE". I-coenzyme pyrroloquinoline quinone (PQQ) inokwandisa ubomi be-nematodes.
• Ziziphi iiNzuzo zeMpiloPQQ ?
I-PQQ iKhuthaza iMitochondria
Kwisifundo sezilwanyana, abaphandi kwiYunivesithi yaseCalifornia bafumanisa ukuba i-PQQ inokukhuthaza ukuveliswa kwe-mitochondria enempilo. Kolu phononongo, emva kokuthatha i-PQQ kwiiveki ezisi-8, inani le-mitochondria emzimbeni liphindwe kabini. Kolunye uphononongo lwezilwanyana, iziphumo zibonise ukuba ukhuseleko lwancitshiswa kakhulu kwaye inani le-mitochondria lancitshiswa ngaphandle kokuthatha i-PQQ. Xa i-PQQ yongezwa kwakhona, ezi mpawu zabuyiselwa ngokukhawuleza.
Ukunciphisa ukuvuvukala kunye nokukhusela i-arthritisAntioxidant & nokhuseleko lwe-nerve
Abantu abadala basoloko bekhathazwa sisifo samathambo, nto leyo ekwayinto ebalulekileyo ekhokelela kwisiphene. Uphononongo lubonise ukuba izinga lokufa lilonke lezigulane ezine-rheumatoid arthritis yi-40% ephezulu kuneyabantu ngokubanzi. Ke ngoko, uluntu lwezenzululwazi luye lwafuna iindlela zokuthintela kunye nokunciphisa isifo samathambo. Uphononongo olusanda kupapashwa kwijenali yoKudumba lubonisa ukubaPQQinokuba ngumsindisi we-arthritis abaphandi abaye bafuna.
Kulingo lwezonyango lomntu, izazinzulu ziye zalinganisa ukudumba kwe-chondrocyte kwityhubhu yovavanyo, zafaka i-PQQ kwiqela elinye leeseli, kwaye azizange zitofe elinye iqela. Iziphumo zibonise ukuba inqanaba le-collagen enzymes ehlazisayo (i-matrix metalloproteinases) kwiqela le-chondrocytes elingazange litofwe nge-PQQ linyuke kakhulu.
Ngezifundo ze-in vitro kunye ne-vivo, izazinzulu zifumanise ukuba i-PQQ inokuthintela ukukhutshwa kwezinto ezibangela ukudumba ziiseli ze-fibrotic synovial kumalungu, ngelixa inqanda ukusebenza kwezinto ezikhutshelweyo zenyukliya ezibangela ukudumba. Kwangelo xesha, izazinzulu ziye zafumanisa ukuba i-PQQ inokunciphisa umsebenzi wee-enzymes ezithile (ezifana ne-matrix metalloproteinases), ezophula uhlobo lwe-2 collagen kumalungu kunye nokonakalisa amalungu.
I-Antioxidant kunye nokhuseleko lwe-nerve
Uphando luye lwafumanisa ukubaPQQinempembelelo ye-neuroprotective kumonakalo we-rat midbrain neuronal kunye nesifo sika-Parkinson esibangelwa yi-rotenone.
Ukungasebenzi kakuhle kwe-Mitochondrial kunye noxinzelelo lwe-oxidative kuye kwaboniswa ukuba yizona zizathu zimbini ze-Parkinson's disease (PD). Uphononongo lubonise ukuba i-PQQ inesiphumo esomeleleyo se-antioxidant kwaye inokukhusela ngokuchasene ne-cerebral ischemia ngokuxhathisa uxinzelelo lwe-oxidative. Impendulo yoxinzelelo lwe-oxidative ithathwa njengenye yezona ndlela zibalulekileyo ezikhokelela kwi-cell apoptosis. I-PQQ inokukhusela iiseli ze-SH-SY5Y kwi-rotenone (i-agent ye-neurotoxic) -i-cytotoxicity. Izazinzulu zisebenzise unyango lwangaphambili lwe-PQQ ukuthintela i-apoptosis yeseli ye-rotenone, ukubuyisela amandla e-membrane ye-mitochondrial, kunye nokuthintela ukuveliswa kweentlobo ze-oxygen esebenzayo kwi-intracellular (ROS).
Ngokubanzi, uphando olunzulu ngendima yePQQkwimpilo yomzimba kunokunceda abantu bathintele ngcono ukwaluphala.
• Unikezelo ENTSHAPQQUmgubo /IiCapsules/Iitafile/iiGummies
Ixesha lokuposa: Oct-26-2024
