Bacopa monnieri, ekwabizwa ngokuba yi-brahmi ngesiSanskrit kunye ne-brain tonic kwisiNgesi, yimifuno ye-Ayurvedic esetyenziswa ngokuqhelekileyo. Uphononongo olutsha lwezenzululwazi luthi imifuno yaseIndiya yeAyurvedic iBacopa monnieri ibonakaliswe ukunceda ukuthintela isifo sika-Alzheimer (AD). Uphononongo, olupapashwe kwiphephancwadi iScience Drug Target Insights, luqhutywe liqela labaphandi baseMalaysia abavela kwiYunivesithi yaseTaylor eUnited States kwaye bavavanya imiphumo yempilo ye-bacosides, icandelo le-bioactive yesityalo.
Ukucaphula izifundo ezimbini eziqhutywe kwi-2011, abaphandi bathi i-bacosides inokukhusela ingqondo kumonakalo we-oxidative kunye nokuncipha kwengqondo ehambelana neminyaka ngokusebenzisa iindlela ezininzi. Njenge-non-polar glycoside, i-bacosides inokuwela umqobo wegazi-ingqondo ngokusebenzisa i-lipid-mediated passive diffusion elula. Ngokusekwe kwizifundo zangaphambili, abaphandi bathi i-bacosides inokuphucula ukusebenza kwengqondo ngenxa yeepropathi zayo zokutshabalalisa.
Ezinye izibonelelo zempilo zeiibacosideszibandakanya ukukhusela i-neurons kwi-Aβ-induced toxicity, i-peptide edlala indima ephambili kwi-pathogenesis ye-AD kuba inokuhlanganisana kwi-insoluble amyloid fibrils. Olu phononongo lubonisa izicelo ezisebenzayo zeBacopa monnieri kwizicelo zengqondo kunye neuroprotective, kwaye i-phytoconstituents yayo ingasetyenziselwa ukuphuhliswa kwamachiza amatsha.Izityalo ezininzi zemveli ziqulethe imixube eyinkimbinkimbi yeekhompawundi kunye nemisebenzi eyahlukeneyo ye-pharmacological and biological, ingakumbi i-Bacopa monnieri, esetyenziswayo. njengamayeza esintu nakuphuhliso lweemveliso ezichasene nokuguga.
● IiNzuzo ezintandathu zeBacopa Monnieri
1.Yandisa iNkumbulo kunye neNgcaciso
I-Bacopa ineenzuzo ezininzi ezithandekayo, kodwa mhlawumbi iyaziwa ngokukwazi kwayo ukuphucula imemori kunye nokuqonda. Indlela ephambili ngayoBakopakuphucula inkumbulo kunye nokuqonda ngonxibelelwano oluphuculweyo lwe-synaptic. Ngokukodwa, imifuno ikhuthaza ukukhula kunye nokwanda kwe-dendrites, eyandisa ukubonakaliswa kwe-nerve.
Qaphela: I-Dendrites izandiso ze-nerve ze-branch ezifumana iimpawu ezingenayo, ngoko ke ukomeleza ezi "ingcingo" zonxibelelwano lwe-nervous system ekugqibeleni kuphucula umsebenzi wokuqonda.
Uphononongo lufumene ukuba i-Bacoside-A ivuselela iiseli zemithambo-luvo, yenza i-synapses yamkeleke ngakumbi kwiimpembelelo zemithambo-luvo ezingenayo. I-Bacopa nayo ibonakaliswe ukuphucula imemori kunye nokuqonda ngokuvuselela umsebenzi we-hippocampal ngokunyusa umsebenzi weprotein kinase emzimbeni, olawula iindlela ezahlukeneyo zeselula.
Kuba i-hippocampus ibalulekile phantse kuyo yonke imisebenzi yokuqonda, abaphandi bakholelwa ukuba le yenye yeendlela eziphambili zokuba iBacopa iphucule amandla engqondo.
Olunye uphononongo lubonise ukuba isongezelelo semihla ngemihla ngeBacopa monnieri(kwimilinganiselo ye-300-640 mg ngosuku) inokuphucula:
Imemori yokusebenza
Inkumbulo yendawo
Inkumbulo engekho zingqondweni
Ingqalelo
Izinga lokufunda
Ukuqinisa inkumbulo
Umsebenzi wokukhumbula ulibazisekile
Ukukhumbula igama
Inkumbulo ebonakalayo
2.Yehlisa uxinzelelo kunye nokuxhalaba
Enoba yimali, yezentlalo, ngokwasemzimbeni, ngokwengqondo okanye ngokweemvakalelo, uxinezeleko ngowona mbandela uphambili kubomi babantu abaninzi. Ngoku kunanini na ngaphambili, abantu bafuna ukusaba ngazo naziphi na iindlela eziyimfuneko, kuquka iziyobisi notywala. Noko ke, izinto ezifana neziyobisi notywala zinokuba nemiphumo emibi engqondweni nasemzimbeni.
Usenokuba nomdla wokwazi okoBakopainembali ende yokusetyenziswa njenge-nervous system tonic ukukhulula iimvakalelo zokukhathazeka, ukukhathazeka, kunye noxinzelelo.Oku kungenxa yeempawu ze-adapogenic ze-Bacopa, eziphucula amandla omzimba wethu wokujamelana, ukusebenzisana, kunye nokubuyisela kuxinzelelo (ngokwengqondo, ngokomzimba. , kunye neemvakalelo). I-Bacopa isebenzisa ezi mpawu zokuguquguquka ngokuyinxenye ngenxa yolawulo lwayo lwee-neurotransmitters, kodwa le mifuno yamandulo ikwachaphazela amanqanaba e-cortisol.
Njengoko usazi, i-cortisol yeyona hormone yoxinzelelo lomzimba. Ukuxinezeleka okungapheliyo kunye namanqanaba e-cortisol aphakamileyo angonakalisa ingqondo yakho.Enyanisweni, izazinzulu ze-neuroscientists ziye zafumanisa ukuba uxinzelelo olungapheliyo lunokubangela utshintsho lwexesha elide kwisakhiwo sobuchopho kunye nokusebenza, okukhokelela ekugqithiseni kweeprotheni ezithile ezonakalisa i-neurons.
Uxinzelelo olungapheliyo lukhokelela kumonakalo we-oxidative kwi-neurons, onokuba neziphumo ezahlukeneyo ezibi, kubandakanya:
Ukulahlekelwa yinkumbulo
Ukufa kweeseli ze-neuron
Ukwenziwa kwezigqibo okungafanelekanga
I-atrophy yobunzima bobuchopho.
I-Bacopa monnieri ineepropathi ezinamandla zokunciphisa uxinzelelo, neuroprotective. Izifundo zabantu zibhale iziphumo ze-adapogenic zeBacopa monnieri, kubandakanya nokunciphisa i-cortisol. I-cortisol ephantsi ikhokelela ekunciphiseni iimvakalelo zoxinzelelo, ezingenakuphucula kuphela isimo sengqondo, kodwa nokwandisa ukugxila kunye nemveliso. Ngaphaya koko, ngenxa yokuba iBacopa monnieri ilawula i-dopamine kunye ne-serotonin, inokuthoba uxinzelelo-olwenze utshintsho kwi-dopamine kunye ne-serotonin kwi-hippocampus kunye ne-prefrontal cortex, igxininisa ngakumbi iimpawu ze-adapogenic zesi sityalo.
Bacopa monnieriiphinda ikhulise imveliso ye-tryptophan hydroxylase (TPH2), i-enzyme eyimfuneko kwiintlobo ezahlukeneyo zemisebenzi ye-nervous system, kubandakanywa ne-serotonin synthesis. Okona kubaluleke kakhulu, i-bacoside-A, enye yezithako eziphambili ezisebenzayo kwi-Bacopa monnieri, ibonakaliswe ukunyusa umsebenzi we-GABA. I-GABA yi-neurotransmitter ezolileyo, ethintelayo. I-Bacopa monnieri inokunyusa umsebenzi we-GABA kunye nokunciphisa umsebenzi we-glutamate, onokunceda ukunciphisa iimvakalelo zokukhathazeka ngokunciphisa ukusebenza kwee-neurons ezinokuthi zigqithise. -umoya omhle.
Ixesha lokuposa: Oct-08-2024
