• Yintoni iTetrahydrocurcumin ?
I-Rhizoma Curcumae Longae yi-rhizoma eyomileyo ye-Curcumae Longae L. Isetyenziswa ngokubanzi njengombala wokutya kunye nevumba elimnandi. Ukubunjwa kwayo kweekhemikhali kubandakanya i-curcumin kunye neoli eguqukayo, ngaphandle kwe-saccharides kunye ne-sterols. I-Curcumin (i-CUR), njenge-polyphenol yendalo kwisityalo se-curcuma, ibonakaliswe ukuba ineempembelelo ezahlukeneyo ze-pharmacological, ezibandakanya i-anti-inflammatory, i-antioxidant, i-oxygen free radical elimination, ukukhusela isibindi, i-anti-fibrosis, i-anti-tumor umsebenzi kunye nokuthintela. yesifo sika-Alzheimer (AD).
I-Curcumin ixutywe ngokukhawuleza emzimbeni kwi-glucuronic acid conjugates, i-sulfuric acid conjugates, i-dihydrocurcumin, i-tetrahydrocurcumin, kunye ne-hexahydrocurcumin, eguqulwa ibe yi-tetrahydrocurcumin. Izifundo zovavanyo ziqinisekisile ukuba i-curcumin inozinzo olubi (jonga i-photodecomposition), i-solubility yamanzi ephantsi kunye ne-bioavailability ephantsi. Ke ngoko, eyona nxalenye yayo ye-metabolic i-tetrahydrocurcumin emzimbeni iye yaba yindawo yophando ekhaya nakwamanye amazwe kwiminyaka yakutshanje.
Tetrahydrocurcumin(THC), njengeyona metabolite esebenzayo kunye neyona nto iphambili ye-curcumin eveliswa ngexesha le-metabolism kwi-vivo, inokuhlukaniswa ne-cytoplasm yamathumbu amancinci kunye nesibindi emva kokulawulwa kwe-curcumin kumntu okanye kwimouse. I-molecular formula yi-C21H26O6, ubunzima be-molecular yi-372.2, ubuninzi be-1.222, kunye ne-melting point yi-95℃-97℃.
• Ziziphi iiNzuzoTetrahydrocurcuminKukhathalelo Lolusu?
1. Impembelelo kwimveliso ye-melanin
I-Tetrahydrocurcumin inokunciphisa umxholo we-melanin kwiiseli ze-B16F10. Xa imilinganiselo ehambelanayo ye-tetrahydrocurcumin (25, 50, 100, 200μmol / L) inikwe, umxholo we-melanin wehla ukusuka kwi-100% ukuya kwi-74.34%, 80.14%, 34.37%, 21.40%, ngokulandelanayo.
I-Tetrahydrocurcumin inokuthintela umsebenzi we-tyrosinase kwiiseli ze-B16F10. Xa i-concentration ehambelanayo ye-tetrahydrocurcumin (i-100 kunye ne-200μmol / L) yanikezelwa kwiiseli, umsebenzi we-intracellular tyrosinase wehla ukuya kwi-84.51% kunye ne-83.38%, ngokulandelanayo.
2. Anti-photoaging
Nceda ubone umzobo we mouse ongezantsi: Ctrl (ulawulo), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg/kg, inyibilikiswe kwi-0.5% sodium carboxymethyl cellulose). Iifoto zesikhumba ngasemva kweegundane ze-KM kwiiveki ze-10 emva konyango olukhethiweyo lwe-THC kunye ne-UVA irradiation. Amaqela ahlukeneyo anemitha ye-UVA flux elinganayo ukuya ebudaleni obukhanyayo avavanywa ngamanqaku eBissett. Amaxabiso abonisiwe kukutenxa komgangatho ophakathi (N = 12/ iqela). *P<0.05, **P
Ukusuka kwinkangeleko, xa kuthelekiswa neqela eliqhelekileyo lokulawula, ulusu lweqela lokulawula imodeli lwalunobunzima, i-erythema ebonakalayo, izilonda, imibimbi enzulu kwaye yaqina, ihamba kunye noshintsho olufana nesikhumba, olubonisa into eqhelekileyo yokufota. Xa kuthelekiswa neqela lokulawula imodeli, iqondo lomonakalo wetetrahydrocurcuminIqela le-100 mg / kg laliphantsi kakhulu kunelo qela lokulawula imodeli, kwaye akukho sikhumba kunye ne-erythema efunyenwe esikhumbeni, kuphela i-pigmentation encinci kunye nemibimbi emihle yabonwa.
3. I-antioxidant
I-Tetrahydrocurcumin inokunyusa izinga le-SOD, inciphise izinga le-LDH kwaye inyuse izinga le-GSH-PX kwiiseli ze-HaCaT.
Ukucoca i-DPPH iiradicals zasimahla
Itetrahydrocurcuminisisombululo sihlanjululwe ngu-10, 50, 80, 100, 200, 400, 800, 1600 amaxesha ngokulandelelana, kwaye isisombululo sesampuli sixutywe ngokucokisekileyo kunye ne-0.1mmol / L isisombululo se-DPPH kumlinganiselo we-1: 5. Emva kokusabela kwiqondo lokushisa kwegumbi le-30min, ixabiso lokuxhamla linqunywe kwi-517nm. Isiphumo siboniswe kumzobo:
4. Ukuthintela ukuvuvukala kwesikhumba
Uphononongo lokulinga lubonise ukuba ukuphiliswa kwenxeba kweempuku kwabonwa ngokuqhubekayo kangangeentsuku ezili-14, xa ijeli ye-THC-SLNS yayisetyenziswa ngokulandelelanayo, isantya sokupholisa isilonda kunye nesiphumo se-THC kunye nolawulo olulungileyo lwalukhawuleza kwaye lungcono, i-odolo yokwehla yayiyijeli ye-THC-SLNS. >
I-THC > Ulawulo oluhle.
Apha ngezantsi kukho imifanekiso emele imodeli yegundane elicinyiweyo kunye nokuqwalaselwa kwe-histopathological, i-A1 kunye ne-A6 ebonisa ulusu oluqhelekileyo, i-A2 kunye ne-A7 ebonisa ijeli ye-THC SLN, i-A3 kunye ne-A8 ebonisa ulawulo oluhle, i-A4 kunye ne-A9 ebonisa ijeli ye-THC, kunye ne-A5 kunye ne-A10 ebonisa okuqinileyo okungenanto. i-lipid nanoparticles (SLN), ngokulandelanayo.
• Ukusetyenziswa kweTetrahydrocurcuminKwizinto zokuthambisa
1.Imveliso zokhathalelo lolusu:
Iimveliso ezichasene nokuguga:Isetyenziswe kwi-anti-aging creams kunye ne-serums ukunceda ukunciphisa imibimbi kunye nemigca emihle kunye nokuphucula ukuqina kwesikhumba.
Iimveliso ezimhlophe:Yongezwa kwizinto ezimhlophe kunye ne-creams ukunceda ukuphucula ithoni yesikhumba kunye namabala angalinganiyo.
2.Iimveliso ezichasene nokudumba:
Isetyenziswa kwiimveliso zokhathalelo lwesikhumba ezifana nokuthomalalisa kunye nokulungisa iikhrimu zokunciphisa ububomvu kunye nokucaphuka.
3.Ukucoca iimveliso:
Yongeza kwizinto zokucoca kunye ne-exfoliants ukunceda ukucoca ulusu kunye nokubonelela ngeenzuzo ze-antibacterial ukukhusela i-acne.
4.Iimveliso zelanga:
Isebenza njenge-antioxidant yokuphucula ukusebenza kwe-sunscreen kunye nokukhusela ulusu kwimitha ye-UV.
5.Imaski yobuso:
Isetyenziswe kwiimaski ezahlukeneyo zobuso ukubonelela ngesondlo esinzulu kunye nokulungiswa, ukuphucula ukuthungwa kwesikhumba.
Tetrahydrocurcuminisetyenziswa kakhulu kwizinto zokuthambisa, ukugubungela ukunakekelwa kwesikhumba, ukucoca, ukukhuselwa kwelanga kunye nezinye iindawo. Ithandwa ngenxa ye-antioxidant, i-anti-inflammatory and whitening effects.
Ixesha lokuposa: Oct-10-2024
